Lack of effects of an acute ileal perfusion of short chain fatty
acids on glucose metabolism in healthy men.
Alamowitch, C., J. Boillot, A. Boussairi, A. Ruskone-Fourmestraux, A.
Chevalier, S. W. Rizkalla, F. Guyon, F. R. J Bornet, G. Slama.
Laboratoire de Diab[acute]etologie-INSERM U 341,
H[circumflex]opital de l'H[circumflex]otel-Dieu, 1 place du parvis
Notre-Dame, 75004 Paris, France, Eridania Beghin-Say, Vilvoorde
Research & Development Centre, Nutrition & Health Department,
Havenstraat 84, 1800 Vilvoorde, Belgium, Laboratoire de Biochimie,
H[circumflex]opital de l'H[circumflex]otel-Dieu, 1 place du parvis
Notre-Dame, 75004 Paris, France
APStracts 3:0053E, 1996.
Dietary fiber intake is associated with several beneficial effects on
carbohydrate metabolism Some authors have speculated that this
improvement may be due to short chain fatty acids (SCFA) produced by
the colonic fermentation of dietary fibers. To test this hypothesis,
6 healthy men aged 26+/-2 years (mean+/-SEM), BMI of 20.9+/-0.7
received on three occasions a 18 hour ileal perfusion infused at a
flow rate of 3.3 ml.min-1, containing either 90 mmol/l of SCFA (60%
acetate, 25% propionate and 15% butyrate)(A), or SCFA during the
first 12 hours then a saline solution (A/S), or a saline solution
(S). Basal hepatic glucose production (BHGP), insulin sensitivity (3
step euglycemic hyperinsulinic clamp) and erythrocyte insulin binding
(EIB) were studied 12 hours after the beginning of the ileal
perfusion. There was no change in BHGP nor in insulin sensitivity.
Yet, maximal EIB was significantly different, 7.1+/-0.1 (A), 6.8+/
-0.1 (A/S) vs 6.5+/-0.1% (S), (p=0.03). We conclude that acute
administration of SCFA do not significantly alter glucose metabolism
in healthy subjects.
Received 15 September 1995; accepted in final form 22 February
1996.
APS Manuscript Number E448-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 20 March 96