Effects of refeeding of undernourished and insulin treatment of
diabetic neonatal rats on igfs and igfbps.
Goya, L., F. Rivero, M. A. Mart[acute]in, R. Arahuetes, E. R.
Hern[acute]andez, and A. M. Pascual-Leone.
Instituto de Bioqu[acute]imica (Centro Mixto CSIC-UCM). Facultad de
Farmacia, Ciudad Universitaria, 28040 Madrid, Spain, Departamento de
Fisiolog[acute]ia Animal. Facultad de Ciencias Biol[acute]ogicas.
Ciudad Universitaria, 28040 Madrid, Spain
APStracts 3:0056E, 1996.
The effect of refeeding and insulin treatment of undernourished and
diabetic neonatal rats, respectively, on the regulation of IGFs and
IGFBPs was investigated. The changes in body weight, insulinemia,
glycemia, serum IGF-I and GH as well as the increase of the 30 Kda
IGFBPs in undernourished and diabetic neonatal rats previously shown
elsewhere, were reversed by refeeding and insulin treatment
respectively. Also, changes in liver mRNA expression of IGF-I and
-II, and IGFBP1 and 2 were restored in refed undernourished and IGF-I
and IGFBP1 levels recovered in insulin-treated diabetic rats.
However, serum GH was still below normal after rehabilitation in both
situations. Thus, the present results support the idea of a GH
-independent IGF/IGFBP regulation, mediated by a balance of insulin
and nutrients as has already been suggested in previous neonatal
studies.
Received 30 October 1995; accepted in final form 1 March 1996.
APS Manuscript Number E515-5.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 20 March 96