Enhanced colonic na+ absorption in cf versus normal mice.
Grubb, B. R., and R. C. Boucher.
Cystic Fibrosis/Pulmonary Research and Treatment Center, School of
Medicine, The University of North Carolina at Chapel Hill, Chapel
Hill, NC
APStracts 3:0161G, 1996.
Because there are reports that electrogenic Na+ absorption is
increased in colonic epithelia of cystic fibrosis (CF) subjects, we
tested whether amiloride (amil)-sensitive Na+ absorption was
increased in the colonic epithelia of CF mice compared to normal mice
on high or low salt diets. When mice consumed a diet high in Na+,
none of the colonic regions [distal colon (d.c.), proximal colon, or
cecum] from either group of mice exhibited an amil-sensitive short
circuit current (Isc). However, when mice were placed on a low Na+
diet for two weeks, all three intestinal regions from the CF mice
exhibited a significant response to amiloride (p
Received 10 November 1995; accepted in final form 12 August 1996.
APS Manuscript Number G481-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 29 August 1996