Parietal cell map kinases: multiple activation pathways.
Nakamura, K., C. J. Zhou, J. Parente, and C. S. Chew.
Institute of Molecular Medicine and Genetics, Medical College of
Georgia, Augusta, GA USA
APStracts 3:0039G, 1996.
Epidermal growth factor (EGF) is a potent mitogen for many cell types;
however, the best known effect of EGF on gastric parietal cell HCl
secretion is the inhibition of this response. Using rabbit parietal
cells in primary culture we have recently shown that the effect of
EGF is biphasic with acute inhibition followed by sustained
enhancement of acid secretory-related responses. At that time, we
hypothesized that EGF might activate a MAP kinase signaling pathway
in parietal cells, and this pathway might play a role in mediating
the sustained and/or the acute effect of EGF on parietal cell acid
secretory-related functions (Chew et al., Am. J. Physiol. 267
(Gastrointest. Physiol. 30): G818-826, 1994).
Received 31 October 1995; accepted in final form 5 February 1996.
APS Manuscript Number G474-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 14 February 96