Neural control of canine small intestinal motility during non
-nutrient infusion.
Behrns, Kevin E., Michael G. Sarr, Russell B. Hanson, Alan R.
Zinsmeister.
From the Department of Surgery, the Gastroenterology Research Unit,
and the Department Health Sciences Research, Mayo Clinic and Mayo
Foundation, Rochester, MN
APStracts 3:0019G, 1996.
Our aim was to determine the effect of in situ neural isolation of the
jejunoileum (extrinsic denervation and disruption of enteric neural
continuity with the duodenum) on spread of single pressure waves
(SPWs) and clustered contractions (CCs) in response to increasing
rates of isolated duodenal and jejunoileal non-nutrient infusions.
Ten dogs were prepared with duodenal and jejunal infusion and
manometry catheters and a diverting proximal jejunal cannula. Five of
the dogs also underwent in situ neural isolation of the entire
jejunoileum. A noncaloric solution was infused at 0-15 ml/min into
proximal duodenum or jejunum while collecting manometric data.
Alterations in direction, distance, and velocity of spread of SPWs
and CCs with increasing rates of intestinal infusion were analyzed by
linear regression of responses to increasing infusion rates. Neural
isolation of the jejunoileum did not alter markedly characteristics
of duodenal or jejunal SPWs or CCs under conditions of no intestinal
infusion. After neural isolation of jejunoileum, increasing rates of
jejunal infusion decreased both the proportion and distance of
antegrade spread of SPWs in duodenum. These findings suggest that
extrinsic innervation to the jejunoileum and enteric neural
continuity with the duodenum do not regulate jejunal SPWs or CCs.
Increasing rates of non-nutrient intestinal infusions do not alter
local motor patterns in the innervated or neurally isolated jejunum,
but after neural isolation of the jejunoileum, these infusions do
alter characteristics of duodenal SPWs by mechanisms independent of
neural pathways.
Received 18 May 1995; accepted in final form 11 January 1996.
APS Manuscript Number G210-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 29 January 96