The effects of increasing the size of the solid component of a
mixed solid/liquid meal on solid and liquid gastric emptying.
Collins, P. J., M. Horowitz, A. Maddox, J. C. Myers, B. E. Chatterton.
Departments of Nuclear Medicine, Medicine and Surgery, Royal
Adelaide Hospital, North Terrace, Adelaide, South Australia,
Australia, 5000
APStracts 3:0046G, 1996.
This study evaluated the hypothesis that an increase in the volume of
the solid component of a mixed solid/nutrient liquid meal will result
in more rapid emptying of solid, but slower liquid emptying. Eight
normal volunteers were studied on two occasions after ingesting a
meal containing 150 ml of 10% dextrose with either 100 g
("small") or 400 g ("large") of ground beef. Subjects
ingested the solid component before the liquid. For solid, the lag
phase was longer for the larger meal (56 min V's 31 min, p <
0.001). However, the absolute emptying rate for the proximal stomach
and the post-lag emptying rate of solid from the total stomach, when
expressed as kcal/min, were greater with the larger meal (p <
0.002). The lag phase was prolonged (p< 0.03) and the rate of
emptying of liquid from the total and proximal stomach slower (p
< 0.001)) with the "large" when compared to the
"small" meal. The total amount of energy delivered to the
duodenum (from solid and liquid components) after the solid lag phase
was greater for the larger meal (4.8 kcal/min V's 2.5 kcal/min, p
< 0.002). These results indicate that an increase in the volume
of the solid component of a mixed solid/liquid meal (i) prolongs the
lag phase, but accelerates the post-lag emptying rate of solid and
(ii) retards GE and intragastric distribution of liquid.
Received 11 August 1995; accepted in final form 8 February 1996.
APS Manuscript Number G349-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 March 96