Physiologic mechanisms of cholecystokinin action on pancreatic
secretion.
Owyang, Chung.
Division of Gastroenterology, Department of Internal Medicine,
University of Michigan Medical Center, Ann Arbor, Michigan 48109
APStracts 3:0090G, 1996.
Recent experimental studies in animals and humans provide strong
evidence that cholecystokinin (CCK) acts via cholinergic pathways to
mediate pancreatic enzyme secretion. These studies indicate that the
sites of CCK's action to stimulate pancreatic secretion are dose
dependent. Doses of CCK that produce physiological plasma CCK levels
act via stimulation of the vagal afferent pathway originated from the
gastroduodenal mucosa, whereas doses that produce supraphysiological
CCK levels act to stimulate intrapancreatic neurons and pancreatic
acini. These CCK sensitive fibers are also responsive to a wide range
of chemical and osmotic stimuli. In this manner gastrointestinal
afferents responding to hormones such as CCK and the ever changing
chemical and physical luminal environment provide sensory information
to the CNS which in turn stimulates pancreatic secretion via a vagal
cholinergic pathway.
Received 19 March 1996; accepted in final form 27 March 1996.
APS Manuscript Number G107-6.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 8 May 96