Human pancreatic enzyme and intestinal motor responses to a meal:
association with duodenal and ileal nutrient delivery .
Keller, Jutta, Michael R[umlaut]unzi, Harald Goebell, Peter Layer.
Dept Medicine, Israelitisches Krankenhaus, Hamburg, Div
Gastroenterology, Dept Medicine, University of Essen, Germany
APStracts 3:0211G, 1996.
Background: It is assumed that in humans, pancreatic and
gastrointestinal motor responses to a meal are coordinated and are
regulated mainly by duodenal nutrient exposure. On the other hand,
there is evidence that the distal intestine may participate in the
regulation of gastrointestinal functions. Aims: The aim of this study
was to compare human pancreatic and intestinal motility responses to
a meal, and to correlate them with nutrient exposure of the proximal
and distal intestine. Methods: Following intubation with an oroileal
multilumen tube for marker perfusion, duodenal and ileal aspiration
and intestinal manometry, fourteen healthy subjects received a mixed
test meal (1257 kJ). Intraluminal nutrient concentrations, enzyme
activities and small intestinal motility were analyzed for 6
postprandial hours. Results: Duration of duodenal nutrient exposure
was 3.4+/-0.2 h, and of pancreatic enzyme response and fed motor
pattern 2.5+/-0.2 h and 3.5+/-0.3 h, respectively. Durations of
pancreatic secretory and motor responses were correlated
(p<0.05), but neither duration of digestive secretory nor of
motor activity correlated with that of prandial duodenal nutrient
concentrations. By contrast, they were associated with the relative
increase in ileal nutrient delivery late postprandially
(p<0.05). Conclusions: Physiological late postprandial
delivery of nutrients to distal intestinal sites is correlated with
the termination of digestive pancreatic and motor responses, and may
participate in their control.
Received 19 March 1996; accepted in final form 1 October 1996.
APS Manuscript Number G1-6.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 5 November 1996