The protective effects of interleukin-11 (il-11) in a murine model
of ischemic bowel necrosis.
Du, Xunxiang, Qi Liu, Zhixiang Yang, Attilio Orazi, Frederick J
Rescorla, Jay L Grosfeld, and David A Williams.
Section of Pediatric Hematology/Oncology, Herman B Wells Center for
Pediatric Research, James Whitcomb Riley Hospital for Children;
Section of Pediatric Surgery, Department of Surgery; Division of
Hematopathology, Department of Pathology and Laboratory Medicine;
Howard Hughes Medical Institute, Indiana University School of
Medicine, Indianapolis, Indiana 46202, USA
APStracts 3:0239G, 1996.
The present study examined the effect of interleukin-11 (IL-11) in a
murine model of bowel ischemia (BI). Prophylactic IL-11
administration in BI mice (induced by occluding the superior
mesenteric artery for 90 minutes) was associated with significantly
decreased morbidity and mortality. IL-11 treated mice demonstrated
rapid recovery of intestinal mucosa evidenced by an increase in
mitotic activity and suppression of apoptosis in intestinal crypt
cells as well as increased peripheral platelet and leukocyte counts
primarily due to an increase in peripheral lymphocyte number in BI
mice. In contrast to vehicle-treated mice which uniformly developed
thrombocytopenia after ischemic injury, no IL-11 treated BI mice
developed thrombocytopenia during the experimental period. These data
suggest a role for IL-11 in the treatment of gastrointestinal mucosal
diseases due to a wide variety of causative injuries.
Received 27 March 1996; accepted in final form 10 October 1996.
APS Manuscript Number G110-6.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996