Local regulation of ileal tone in healthy humans.
Coffin, Benoit, Marc L[acute]emann, Bernard Flouri[acute]e, Pauline
Jouet, Jean-Claude Rambaud, and Raymond Jian.
Unit[acute]e de Recherche sur les Fonctions Intestinales, le
M[acute]etabolisme et la Nutrition, INSERM U 290, H[circumflex]opital
Saint-Lazare and H[circumflex]opital Saint-Louis, PARIS, FRANCE
APStracts 3:0175G, 1996.
We previously showed that meal induced in the human terminal ileum a
delayed tonic relaxation which could be related to the ileal delivery
of meal residues and/or endogenous secretions released by meal. In
this study, we assessed the effects of some components of the ileal
contents on its motor activity. In 6 healthy subjects we studied
ileal tonic and phasic motility in response to the infusion into the
terminal ileum of different isotonic solutions : saline,
glycochenodeoxycholic acid (GDCA), triglycerides, and short-chain
fatty acids (SCFAs). Tonic activity was not modified by saline, while
it was significantly decreased by GDCA and triglycerides (maximal
increase in intrabag volume 139 +/- 7% and 152 +/- 16%, respectively,
P < 0.01), and significantly increased by SCFAs (maximal
decrease in intrabag volume 72 +/- 4 %, P < 0.01). No
significant change of phasic activity was evidenced with either
solutions. We conclude that 1) bile acids and triglycerides not
absorbed in the more proximal gut could be involved in the ileal
relaxation occurring after eating, 2) local stimulation of
chemoreceptors is of importance in the regulation of ileal motility.
Received 13 November 1995; accepted in final form 26 August 1996.
APS Manuscript Number G484-5.
Article publication pending Am. J. Physiol. (Gastrointest. Liver
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 19 September 1996