Pulmonary distribution of iodoantipyrine: temperature and lipid
solubility effects.
Chinard, Francis P., Guy Basset, William O. Cua, Georges Saumon,
Francine Bouchonnet, Rita A. Garrick, and Vivien Bower.
Departments of Medicine and of Pharmacology and Physiology,
University of Medicine and Dentistry, New Jersey Medical School,
Newark, New Jersey 07103- 2714 and Institut National de Sant[acute]e
et de la Recherche M[acute]edicale, U 82, Facult[acute]e de
M[acute]edecine, Xavier Bichat, Paris, 75018 and Department of
Natural Science, Fordham University, The College at Lincoln Center,
New York, NY 10023
APStracts 3:0537H, 1996.
Chinard, Francis, P., Guy Basset, William O. Cua, Georges Saumon,
Francine Bouchonnet, Rita A. Garrick, and Vivien Bower. Pulmonary
distribution of iodoantipyrine: temperature and solubility effects.
Am. J. Physiol. 000 (Heart Circ. Physiol. 00):0000-0000, 1996. In
multiple indicator dilution studies in rat and dog lungs, we have
found that the distribution of iodoantipyrine, IAP, is not limited by
the endothelium at T > 7oC but is barrier limited at the
epithelium at T < 15oC (permeability coefficient of 6.3 x 10-5
cm x s-1 at 8oC). IAP extraction from the vascular surface to tissues
is greater than that of antipyrine, AP, and than that of THO. IAP
transmittance from the alveolar surface to the vascular compartment
is smaller than that of AP and that of THO: a lung lipid compartment,
probably in the lamellar bodies of the Type II cells, is more
accessible to IAP than to AP or THO because IAP has higher oil:water
distribution coefficient. Our mathematical model takes into account
these matters and also the low surface density of the Type II cells:
some of the IAP may by-pass the lipid compartment. Lipid may affect
the transit of solutes with high oil-water distribution coefficients
in the lungs and across the alveolar-capillary barrier.
Received 19 August 1996; accepted in final form 2 December 1996.
APS Manuscript Number H726-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996