APStracts 3:0199H, 1996.

Effect of nutritional state on myocardial substrate metabolism and contractile function in normal and postischemic myocardium. Montessuit, Christophe, Ir[grave]ene Papageorgiou, Isabelle Tardy, and Ren[acute]e Lerch. Cardiology, Department of Internal Medicine, University Hospital, 1211 Geneva, Switzerland

APStracts 3:0199H, 1996.

The pattern of substrate utilization may influence postischemic myocardial injury. To characterize the effect of nutritional state on substrate selection and contractile function during control conditions and postischemic reperfusion, hearts from fed and fasted rats were perfused retrogradely with 0.4 mM palmitate, 8 mM glucose and 175 mU/l insulin. Under control conditions hearts from fasted rats exhibited lower glucose oxidation as compared to hearts from fed rats (-59%) and higher palmitate oxidation (+191%).

Received 17 July 1995; accepted in final form 19 April 1996.
APS Manuscript Number H668-5.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 8 May 96