Effects of hemodilution on gastric regional perfusion and
intramucosal ph.
Kleen, Martin, Oliver Habler, J[diaeresis]org Hutter, Armin
Podtschaske, Mathias Tiede, Gregor Kemming, Martin Welte, Carlos
Corso, and Konrad Messmer.
Institute for Surgical Research and Institute of Anesthesiology,
University of Munich, Marchioninistr 15, 81366 Munich, Germany,
Hemodilution, Gastric Perfusion and pHi
APStracts 3:0207H, 1996.
Acute normovolemic hemodilution (ANH) has been shown to be a cost
-effective method of reducing allogenic blood transfusion during
elective surgery. ANH has been implicated with impaired oxygenation
in isolated canine gastric flaps. The present study was designed to
investigate the effects of ANH on gastric mucosal oxygenation using a
model closely imitating the clinical situation. 16 splenectomized,
anesthetized beagles were isovolemically hemodiluted to a hematocrit
of 20+/-1% (HES 6% 200.000/0.45-0.55). Blood volume (indocyanin
green), cardio-respiratory parameters, gastric intramucosal ph (pHi)
and gastric regional blood flow (radioactive microspheres _ 15 [mu]m)
were measured before and after ANH. Results: Blood volume was
unchanged: 87 +/- 8 ml/kg before, 88 +/- 7 ml/kg after ANH. Median
total gastric mucosal blood flow at baseline was 0.51+/-0.35 ml/min/g
and did not change significantly upon ANH. The mean pHi was 7.29+/
-0.05 before and 7.28+/-0.05 after hemodilution. There was a
homogenization of blood flow distribution in gastric mucosa. Severe
hemodilution to hct of 20% does not impair gastric mucosal
oxygenation and poses no risk to gastric mucosal integrity.
Received 6 March 1996; accepted in final form 30 April 1996.
APS Manuscript Number H221-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 19 May 96