Effect of reperfusion on ventricular mass, topography and function
during healing of anterior infarction.
Jugdutt, Bodh I.
Division of Cardiology, Department of Medicine, University of
Alberta, Edmonton, Alberta
APStracts 3:0449H, 1996.
The effect of reperfusion made 2 hours after left anterior descending
coronary artery occlusion on in vivo changes (echocardiograms) in
ventricular mass, topography and function during postinfarction
healing over 6 weeks and postmortem topography (planimetry) and
collagen (hydroxyproline) at 6 weeks were measured in dogs randomized
to reperfusion (n=12) and no reperfusion (n=12). Compared to no
reperfusion over the 6 weeks, reperfusion resulted in less increase
in systolic and diastolic volumes, less increase in ventricular mass,
less infarct wall thinning and mild improvement in global ejection
fraction without any change in regional asynergy. Although
reperfusion decreased infarct collagen content at 6 weeks, it reduced
in vivo expansion of the endocardial surface area, reduced the
elongation, diastolic bulge, echogenicity and systolic thinning of
the infarct zone, and reduced global shape index and aneurysm
frequency. Thus, reperfusion after 2 hours attenuates regional and
global dilation and produces less increase in mass during postinfarct
healing than no reperfusion, so that the improvement in global
systolic function cannot be attributed to global hypertrophy.
Received 29 May 1996; accepted in final form 30 September 1996.
APS Manuscript Number H481-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 5 November 1996