Treatment with 5-hydroxytryptamine potentiates development of
pulmonary hypertension in chronically hypoxic rats.
Eddahibi, Saadia, Bernadette Raffestin, Isabelle Pham, Jean-Marie
Launay, Philippe Aegerter, Maryvonne Sitbon, Serge Adnot.
D[acute]epartement de physiologie et INSERM U 296, CHU Henri
Mondor, 94010 Cr[acute]eteil, France, D[acute]epartement de
physiologie, Universit[acute]e Ren[acute]e Descartes,
H[circumflex]opital Ambroise Par[acute]e, 92100 Boulogne, France
APStracts 3:0462H, 1996.
The aim of this study was to investigate the potential role of 5
-hydroxytryptamine (5-HT) on development of pulmonary hypertension
during chronic exposure to mild (15 %) and severe (10 % O2) hypoxia.
In isolated lungs from normoxic rats preconstricted with U-46619, 5
-HT (10-12 - 10-8 M) induced dose-dependent vasodilation (n = 6),
which was suppressed by the NO synthesis inhibitor, Nitro-L-arginine
methyl ester (L-NAME,
Received 30 April 1996; accepted in final form 11 September 1996.
APS Manuscript Number H384-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996