Regional myocardial effects of intracoronary bradykinin in
conscious dogs.
Houel, R[acute]emi, Jinbo Su, Fabrice Barbe, R[acute]emi Choussat,
Bertrand Crozatier, and Luc Hittinger.
Institut National de la Sant[acute]e et de la Recherche
M[acute]edicale (INSERM), U400, Facult[acute]e de M[acute]edecine,
94010 Cr[acute]eteil, FRANCE
APStracts 3:0463H, 1996.
This study was undertaken to examine in conscious dogs, the coronary
and regional myocardial effects of intracoronary (ic) bradykinin (BK)
and their modulation by an angiotensin converting enzyme inhibitor.
Eleven dogs were chronically instrumented with a left ventricular
(LV) micromanometer, a circumflex coronary catheter and flow probe,
and ultrasonic crystals in the LV posterior wall. In the absence of
systemic hemodynamic changes, ic BK (0.1-10 ng/kg) produced a dose
-dependent increases in coronary blood flow velocity (CBFv) and in LV
posterior end-diastolic wall thickness (EDWT) but no change in LV
regional myocardial function as assessed by LV posterior systolic
wall thickening. The increases in LV EDWT and in CBFv were linearly
correlated. The bradykinin B2 antagonist (Hoe 140) abolished the
effects of BK. Intracoronary enalaprilat (0.75 mg) extended the
duration of the effect of BK on CBFv without modification of peak
responses and induced a further increase in LV posterior EDWT but no
change in LV regional myocardial function. Thus, in conscious dog,
the vasodilator effect of ic bradykinin alone or modulated by
enalaprilat is not associated with changes in LV regional myocardial
function.
Received 14 May 1996; accepted in final form 24 September 1996.
APS Manuscript Number H436-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996