Basic fibroblast growth factor restores endothelium-dependent
responses of hypercholesterolemic rabbit thoracic aorta.
Meurice, Thibaud, Christophe Bauters, Benoit Vallet, Delphine
Corseaux, Eric Van Belle, Martial Hamon,bernard Dupuis, Jean-Marc
Lablanche, Michel E. Bertrand.
Departments of Pharmacology, Cardiology and Anesthesiology,
University of Lille, 59037 Lille Cedex, France
APStracts 3:0407H, 1996.
In animal models, an hypercholesterolemic diet induces areas of
deendothelialization and impairs endothelium-dependent
vasorelaxation. Angiogenic growth factors have been shown to increase
endothelial cell growth in vivo. This study was thus designed to test
the hypothesis that chronic administration of basic fibroblast growth
factor (bFGF) in hypercholesterolemic rabbits might restore normal
physiologic responses to endothelium-dependent agonists.
Received 6 May 1996; accepted in final form 26 August 1996.
APS Manuscript Number H399-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 7 October 1996