Regional glucose uptake within hypoperfused swine myocardium as
measured by positron emission tomography .
McFalls, Edward O., Douglas Baldwin, Brad Palmer, David Marx, Diane
Jaimes, and Herbert B. Ward.
Division of Cardiology, VA Medical Center, University of
Minnesota
APStracts 3:0369H, 1996.
Chronic myocardial ischemia and 18F-fluorodeoxyglucose (FDG) uptake
were studied with positron emission tomography in 12 swine
instrumented with an external constrictor on the LAD. Serial changes
in function (ECHO), blood flow (15O-water) and FDG were determined
weekly. At 1 week, function was normal and FDG uptake in LAD and
NonLAD regions was 0.43+/-0.12 and 0.45+/-0.11 [mu]mol/min/g
respectively (NS). At 5 weeks, LAD wall thickening decreased to 18+/
-5% from 27+/-8% (p<0.05) while LAD and NonLAD blood flows were
0.68+/-0.28 and 1.03+/-0.25 ml/min/g respectively (P<0.05). At
that time, FDG uptake in LAD and NonLAD regions was 0.60+/-0.43 and
0.49+/-0.30 [mu]mol/min/g respectively (P<0.05). By transmural
biopsies (n=6), ATP and creatine phosphate in the LAD region was
3.62+/-0.73 [mu]mol/g wet wt and 5.91+/-1.44 [mu]mol/g wet wt
respectively and neither differed from values in remote regions. In
this model of chronic ischemia, hypoperfused, dysfunctional regions
were characterized by enhanced glucose uptake and preserved
bioenergetics. This supports the concept that the myocardium adapts
to chronic ischemia.
Received 19 April 1996; accepted in final form 19 July 1996.
APS Manuscript Number H351-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 19 September 1996