Cardiomyocyte dna synthesis and binucleation during murine
development.
Soonpaa, Mark H., Kyung Keun Kim, Laura Pajak, Michael Franklin, and
Loren J. Field.
Krannert Institute of Cardiology, Indiana University School of
Medicine, 1111 West 10th Street, Indianapolis, IN 46202-4800
APStracts 3:0375H, 1996.
Cardiomyocyte DNA synthesis and binucleation indices were determined
during murine devel opment. Cardiomyocyte DNA synthesis occurred in
two temporally distinct phases. The first phase occurred during fetal
life and was associated exclusively with cardiomyocyte prolifera
tion. The second phase occurred during early neonatal life and was
associated with binuclea tion. Collectively, these results suggest
that cardiomyocyte reduplication ceases during late fetal life.
Northern and Western blot analyses identified several candidate genes
which were differentially expressed during the reduplicative and
binucleation phases of cardiomyocyte growth.
Received 16 April 1996; accepted in final form 22 August 1996.
APS Manuscript Number H336-6.
Article publication pending Am. J. Physiol. (Heart Circ. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 19 September 1996