Effects of salbutamol on rat diaphragm contractility.
Van, H. F. M., Der Heijden, R. H. H. Van Balkom, H. T. M. Folgering,
C. L. A. Van Herwaarden, P. N. R. Dekhuijzen.
Department of Pulmonary Diseases, University Hospital Nijmegen, The
Netherlands
APStracts 3:0190A, 1996.
The aim of this study was to investigate: (I) the effects and time
course of single doses of salbutamol on isometric contractile
properties of isolated rat diaphragm strips, and (II) whether these
effects were caused by a direct effect on the muscle. Two experiments
were performed: (A) salbutamol was administered subcutaneously (sc)
in doses of 12.5, 25, 50, or 100 [mu]g/kg (25 and 50 [mu]g/kg sc
resulted in serum concentrations of 9 and 15 [mu]g/L, respectively,
0.5 hr after injection) and in vitro contractile properties were
determined 0.5, 1, 2 or 4 hrs after administration; (B) salbutamol
was added to the tissue bath in a concentration of
Received 4 April 1995; accepted in final form 2 April 1996.
APS Manuscript Number A9-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 16 April 96