Exercise causes blood glutathione oxidation in chronic obstructive
pulmonary disease. prevention by oxygen therapy.
Vi[tilde]na, Jos[acute]e, Emilio Servera, Miguel Asensi, Juan Sastre,
Federico V. Pallard[acute]o, Jos[acute]e A. Ferrero, Jos[acute]e
Garc[acute]ia-De-La Asunci[acute]on, Vicente Ant[acute]on, and Julio
Mar[acute]in.
Departamento de Fisiolog[acute]ia, Universidad de Valencia, Spain,
Servicio de Neumolog[acute]ia y 3Servicio de Cardiolog[acute]ia,
Hospital Cl[acute]inico, Valencia, Spain
APStracts 3:0352A, 1996.
The aim of the present study was to determine if glutathione oxidation
occurs in chronic obstructive pulmonary disease patients (COPD) who
perform exercise and if this could be prevented. Blood glutathione
red-ox ratio (GSSG/GSH) was significantly increased when patients
performed exercise for a short period of time. This produces
exhaustion in them. Their resting blood GSSG/GSH was: 0.039 +/- 0.008
(mean +/- SD, n=5) and after exercise it was: 0.085+/-0.019, p <
0.01. Glutathione oxidation associated with that exercise was
partially prevented by oxygen therapy (resting value: 0.037 +/-
0.014, n=5, after exercise: 0.047+/-0.016, n=5 p<0.01). We
conclude that light exercise causes an oxidation of glutathione to
COPD patients which can be partially prevented by oxygen therapy.
Received 17 July 1995; accepted in final form 4 July 1996.
APS Manuscript Number A765-5.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 4 August 1996