Effect of endurance training and confounding seasonal fluctuation
on coagulation and fibrinolysis in young sedentary males.
Burg, P. J. M. Van Den, J. E. H. Hospers, M. Van Vliet, W. L. Mosterd,
B. N. Bouma, and I. A. Huisveld.
Department of Medical Physiology and Sports Medicine, and
Department of Haematology, University of Utrecht, The Netherlands,
Training and Hemostasis in Males
APStracts 3:0509A, 1996.
Effect of 12 weeks submaximal training on hemostatic variables was
studied in 20 young sedentary males (TR) and 19 non-training matched
controls (CO). After training, a more pronounced increase in factor
VIII coagulant activity (P < 0.01), reflected in a decrease in
activated partial thromboplastin time (P < 0.01) during
maximal exercise was seen. Both basal plasminogen activator inhibitor
(PAI-1) antigen and activity (P < 0.05), as well as basal and
exercise-induced tissue-type plasminogen activator (t-PA) antigen (P
< 0.05) were decreased after training. The overall effect on
fibrinolysis was reflected in an increase in the t-PA-Act/t-PA Ag
ratio in TR. In contrast, during the same period (February-June), CO
demonstrated an increase in basal PAI-1 antigen and activity (P
< 0.05) and together with an increase in basal and exercise
-induced t-PA antigen (P < 0.05). Both basal and exercise
-induced t-PA Act were unchanged, but the t-PA Act/t-PA Ag ratio was
decreased (P < 0.05) in CO. We conclude that physical training
promotes both coagulation and fibrinolytic potential during exercise,
and may reverse unfavourable seasonal effects on fibrinolysis.
Received 19 March 1996; accepted in final form 24 October 1996.
APS Manuscript Number A270-6.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996