Time course of recovery from nerve injury in skeletal muscle
-energy state and local circulation-.
Hayashi, Yoshihiro, Takaaki Ikata, Hiroaki Takai, Shinjiro Takata,
Takayuki Sogabe, and Keiko Koga.
Department of Orthopedic Surgery, School of Medicine, the
University of Tokushima 770, Japan, Tokushima Research Institute,
Otsuka Pharmaceutical Co.,Ltd. Tokushima 771-01, Japan
APStracts 3:0534A, 1996.
This study examined the time course of recovery from nerve injury on
energy state assessed by phosphorus-31 magnetic resonance
spectroscopy (MRS) and local circulation dynamics by fluorine-19 MRS
in skeletal muscles of rats. The hindlimb muscles undergone
unilateral sciatic nerve compression for 2 weeks (CN) were compared
with sham operated (SO) muscles and with muscles which had the
compression removed after 2 weeks and allowed to recover for 4 weeks
(R4) or for 6 weeks (R6). The energy state and local circulation
dynamics of CN muscles were less than those of SO muscles (p <
0.01). The energy state of R4 muscles remained at levels similar to
CN muscles, whereas the local circulation dynamics improved, but not
back to SO values. In R6 muscles, both parameters returned to SO
values. These results showed that the recovery processes of
circulation precede those of energy state in skeletal muscles.
Received 12 March 1996; accepted in final form 12 November 1996.
APS Manuscript Number A239-6.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996