Nitric oxide response in exhaled air during an incremental
exhaustive exercise.
Chirpaz-Oddou, M. Bf., Favre-Juvin A, Flore P., Eterradossi J.,
Delaire M., Grimbert F. and A. Therminarias.
Facult[umlaut]a de M[umlaut]adecine de Grenoble, Laboratoire de
Physiologie et Service de M[umlaut]adecine du Sport, *timc-preta cnrs
umr 5525, 38700, La Tronche, France
APStracts 3:0575A, 1996.
This study examines the response of the exhaled nitric oxide (NO)
concentration (CNO), and the exhaled NO output (VNO) during
incremental exercise, and during recovery in 6 sedentary women
(Women), 7 sedentary men (Smen) and 8 trained men (Tmen). The
protocol consisted of increasing the exercise intensity by 30 watts
every 3 min until exhaustion, followed by 5 min of recovery.
Ventilation (VE), oxygen consumption (VO2) carbon dioxide production
(VCO2), heart rate (HR), CNO and VNO were measured continuously. The
CNO in exhaled air decreased significantly provided that the exercise
intensity exceeded 65 % of the VO2peak. It reached similar values, at
exhaustion, in all 3 groups. The VNO increased proportionally with
exercise intensity up to exhaustion, and decreased rapidly during
recovery. At exhaustion, the mean values were significantly higher
for Tmen than for Smen and Women. During exercise, VNO correlates
well with VO2, VCO2, VE and HR. For the same sub-maximal intensity,
and thus, a given oxygen consumption, and probably a similar cardiac
output, VNO appeared to be similar in all three groups, even if the
VE was different. These results suggest that, during exercise,
exhaled NO output is mainly related to the magnitude of aerobic
metabolism and that this relationship is not affected by sex
differences or by noticeable differences in the level of physical
training.
Received 25 June 1996; accepted in final form 12 November 1996.
APS Manuscript Number A601-6.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996