Training intensity, blood lipids and apolipoproteins in men with
high cholesterol.
Crouse, Stephen F., Barbara C. O'brien, Peter W. Grandjean, Robert C.
Lowe, J. James Rohack, John S. Green, Homer Tolson.
Applied Exercise Science Laboratory, Department of Health and
Kinesiology, Texas A&M University, College Station, Texas 77843,
Department of Biochemistry/Biophysics, Texas A&M University,
College Station, Texas 77843, Department of Health and Kinesiology,
Texas A&M University, College Station, Texas 77845, Health
Management Center, Baptist Medical Center, Little Rock, Arkansas,
M.D., College of Medicine, Health Science Center, Texas A&M
University, College Station, Texas 77843, Department of Health and
Kinesiology, Texas A&M University, College Station, Texas 77843,
Department of Health and Kinesiology, Texas A&M University,
College Station, Texas 77843
APStracts 3:0442A, 1996.
Twenty-six hypercholesterolemic men ( cholesterol = 258 mg/dL, age =
47 y, weight = 81.9 kg) completed 24 weeks of cycle ergometer
training 3/wk, 350 kcal/session at either high (HI; n=12) or moderate
(MOD; n=14) intensity (80% and 50% O2max, respectively, randomly
assigned) to test the influence of training intensity on blood lipid
and apolipoprotein concentrations. All physiologic, lipid, and
apolipoprotein measurements were completed at 0, 8, 16, and 24 weeks.
Lipid data were analyzed via 2 x 4 repeated measures ANOVA (_ =
0.0031). Training produced a significant decrease in body weight and
increase in O2max. No interactions between intensity and weeks of
training were noted for any lipid or apolipoprotein variable, and no
between-group differences were significant before or throughout
training. Therefore, intensity did not affect the training response.
Regardless of intensity, apo A-I and apo B fell 9% and 13%,
respectively, by week 16 and remained lower through week 24 (p
< 0.0003). Total cholesterol fell transiently (-5.5%) by week
16 (p < 0.0021), but returned to initial levels by week 24.
Triglyceride, low-density lipoprotein cholesterol, and high-density
lipoprotein (HDL) cholesterol did not change with training. In
contrast, HDL2-cholesterol rose 79% by week 8, and 82% above initial
levels by week 24 (p < 0.0018); HDL3-cholesterol fell 8% and
13% over the same training intervals (p < 0.0026). These data
show that changes in blood lipid and apolipoprotein concentrations
which accompany training in hypercholesterolemic men are not
influenced by exercise intensity when caloric expenditure is held
constant.
Received 21 Mardch 1996; accepted in final form 6 September 1996.
APS Manuscript Number A282-6.
Article publication pending Journal of Applied Physiology.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 7 October 1996