Long-Term Depression of Aplysia Sensorimotor Synapses in Cell Culture: Inductive Role of a Rise in Postsynaptic Calcium. Lin, Xiang Y. and David L. Glanzman. Department of Physiological Science, UCLA, 405 Hilgard Avenue, Los Angeles, CA 90095, aBrain Research Institute, UCLA, Los Angeles, CA 90024-1761.
APStracts 3:0116N, 1996.
SUMMARY AND CONCLUSIONS
1. Activation of sensory neurons at 2 Hz for 15 min induces long-term depression (LTD) of isolated Aplysia sensorimotor synapses in cell culture. 2. Prior infusion of the Ca2+ chelator 1,2-bis-(2-aminophenoxy)ethane-N,N ,N tetraacetic acid (BAPTA) into the postsynaptic motor neuron blocks the induction of LTD, but not short-term synaptic depression. 3. Invertebrate central synapses possess the capacity for LTD. This form of long-term synaptic plasticity may play an important role in learning in Aplysia.

Received 7 May 1996; accepted in final form 30 May 1996.
APS Manuscript Number J371-6.
Article publication pending J. Neurophysiol.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 17 June 96