NATURE AND PRECISION OF TEMPORAL CODING IN VISUAL CORTEX: A METRIC-SPACE
Victor, Jonathan D. and Keith P. Purpura.
Department of Neurology and Neuroscience, Cornell University Medical
College, 1300 York Avenue, New York, NY 10021.
APStracts 3:0061N, 1996.
SUMMARY AND CONCLUSIONS
1. We recorded single-unit and multi-unit activity in response to transient
presentation of texture and grating patterns at 25 sites within the parafoveal
representation of V1, V2, and V3 of two awake monkeys trained to perform a
fixation task. In grating experiments, stimuli varied in orientation, spatial
frequency, or both. In texture experiments, stimuli varied in contrast, check
size, texture type, or pairs of these attributes. 2. In order to examine the
nature and precision of temporal coding, we compared individual responses
elicited by each set of stimuli in terms of two families of metrics. One
family of metrics, D spike , was sensitive to the absolute spike time
(following stimulus onset). The second family of metrics, D interval , was
sensitive to the pattern of interspike intervals. In each family, the metrics
depend on a parameter q , which expresses the precision of temporal coding.
For q ? = ? 0, both metrics collapse into the "spike count" metric ( D count
), which is sensitive to the number of impulses but insensitive to their
position in time. 3. Each of these metrics, with values of q ranging from 0 to
512/sec, was used to calculate the distance between all pairs of spike trains
within each dataset. The extent of stimulus-specific clustering manifest in
these pairwise distances was quantified by an information measure. Chance
clustering was estimated by applying the same procedure to synthetic datasets
in which responses were randomly assigned to the input stimuli. 4. 170 of the
352 datasets showed evidence of tuning via the spike count ( q ? = ? 0)
metric. 294 of the 352 datasets showed evidence of tuning via the spike time
metric and 272 of the 352 datasets showed evidence of tuning via the spike
interval metric to the stimulus attribute (contrast, check size, orientation,
spatial frequency, or texture type) under study. Across the entire dataset,
the information not attributable to chance clustering averaged 0.042 bits for
the spike count metric, 0.171 bits for the optimal spike time metric, and
0.107 bits for the optimal spike interval metric. 5. The reciprocal of the
optimal cost q serves as a measure of the temporal precision of temporal
coding. In V1 and V2, with both metrics, temporal precision was highest for
contrast (ca. 10 - 30 msec), and lowest for texture type (ca. 100 msec). This
systematic dependence of q on stimulus attribute provides a possible mechanism
for the simultaneous representation of multiple stimulus attributes in one
spike train. 6. Our findings are inconsistent with Poisson models of spike
trains. Synthetic datasets in which firing rate was governed by a time-
dependent Poisson process matched to the observed post-stimulus time histogram
(PSTH) overestimated clustering induced by D count and, for low values of q ,
D spike [ q ] and D interval [ q ]. Synthetic datasets constructed from a
modified Poisson process which preserved not only the PSTH but also spike
count statistics accounted for the clustering induced by D count , but
underestimated the clustering induced by D spike [ q ] and D interval [ q ].
Received 10 October 1995; accepted in final form 21 February 1996.
APS Manuscript Number J667-5.
Article publication pending J. Neurophysiol.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 27 March 96