Neural Mechanisms of Spatial Selective Attention in Areas V1, V2, and V4 of
Macaque Visual Cortex.
Luck, Steven J., Leonardo Chelazzi, Steven A. Hillyard and Robert Desimone.
Department of Psychology, University of Iowa, Iowa City, Iowa 52242-1407
USA, Laboratory of Neuropsychology, National Institute of Mental Health,
Bethesda, Maryland 20892 USA, Department of Neurological and Visual Sciences,
University of Verona, Verona I-37134 Italy, Department of Neurosciences,
University of California, San Diego, La Jolla, California 92093-0608 USA.
APStracts 3:0239N, 1996.
Many neurons in extrastriate visual cortex have large receptive fields, and
this may lead to significant computational problems whenever multiple stimuli
fall within a single field. Previous studies have suggested that when multiple
stimuli fall within a cell's receptive field, they compete for the cell's
response in a manner that can be biased in favor of attended stimuli. In the
present study, we examined this role of attention in areas V1, V2, and V4 of
macaque monkeys using a behavioral paradigm in which attention was directed to
one of two stimulus locations. When two stimuli were presented simultaneously
inside the cellŐs receptive field (which could be accomplished only in areas
V2 and V4), we found that the cellŐs response was strongly influenced by which
of the two stimuli was attended. The size of this attention effect was reduced
when the attended and ignored stimuli were presented sequentially rather than
simultaneously. In addition, the effects became very weak and inconsistent in
these areas when only one of the two stimuli was located inside the receptive
field. Attention thus modulated sensory responses primarily when two or more
simultaneous stimuli competed for access to a neuron's receptive field. As in
areas V2 and V4, attention did not modulate sensory responses in area V1 when
only a single stimulus was inside the receptive field. In addition, the small
receptive fields in this area precluded the simultaneous presentation of
attended and ignored stimuli inside the receptive field, making it impossible
to determine whether attention effects would be observed under the conditions
that led to consistent attention effects in areas V2 and V4. Spontaneous
firing rates in areas V2 and V4 were found to be 30-40% higher when attention
was directed inside rather than outside the receptive field, even when no
stimulus was present in the receptive field. Spontaneous firing rates also
varied according to the particular location within the receptive field that
was attended. These shifts in spontaneous activity may reflect a top-down
signal that biases responses in favor of stimuli at the attended location.
Received 3 May 1996; accepted in final form 16 September 1996.
APS Manuscript Number J363-6.
Article publication pending J. Neurophysiol.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 5 November 1996