Molecular and Cellular Biology of Thyrotropin-Releasing Hormone Receptors. Gershengorn, Marvin C., and Roman Osman. Cornell Unviersity Medical College and The New York Hospital; and Department of Physiology and Biophysics, Mount Sinai Medical Center, New York, New York.
APStracts 2:0005P, 1996.
ABSTRACT
Thyrotropin-releasing hormone (TRH) receptor (TRH-R) complementary DNAs have been cloned from several species. The deduced amino acid sequences are compatible with TRH-R being a seven-transmembrane-spanning G protein-coupled receptor. These complementary DNAs and reagents derived from them have permitted detailed study of TRH-R biology at the molecular and cellular levels. Studies that have been performed since 1990 are reviewed in this article under the following headings: TRH-R gene, tissue distribution of TRH- R, primary structure of TRH-Rs, three-dimensional structure of the TRH-R binding pocket, TRH-R and G proteins, TRH-R activation, TRH desensitization, TRH-R endocytosis, and regulation of TRH-R number. It is evident that many new insights into the structure, function, and regulation of TRH-R have been gained in the last several years but that our understanding of these processes is incomplete. We look forward to even greater progress in the future. 

APS Manuscript Number P-20-5.
Article publication scheduled January 1996 Physiological Reviews.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 22 January 96