Modulation of Cardiovascular Control Mechanisms and Their Interaction.
Persson, Pontus B”rje.
Physiologisches Insitut der Humboldt, Universitat zu Berlin, Medizinische
Fakultat (Charite), Berlin, Germany.
APStracts 2:0007P, 1996.
ABSTRACT
It is generally held that the role of a specific control element can only be
understood within its physiological environment. The reviewed studies make it
clear that there is a potent interplay between locally produced substances
such as adenosine, nitric oxide, prostaglandins, and various others all
interacting with the central level of control. This can occur at central sites
(e.g., nitric oxide in the brain) or in the periphery (e.g., neural influence
on autoregulation). The interactions are more or less pronounced during
specific physiologiocal challenges. Furthermore, several of these interactions
are altered under pathological circumstances, and in some cases, these
interactions seem to maintain or even augment the severity of disease. When
more than three parameters participate in an interaction, the resulting
regulation may become extremely complex. If these parameters are nonlinearly
coupled with each other, the only way to shed light onto the nature of control
network is by treating it as a black box. With the use of spectral analysis or
nonlinear methods, it is possible to disentangle the fundamental nature of the
system in terms of the complexity and stability. Therefore, modern
developments in cardiovascular physiology utilizing these techniques, some of
which are derived from the "chaos theory," are reviewed.
APS Manuscript Number P-22-5.
Article publication scheduled January 1996 Physiological Reviews.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 22 January 96