Mechanism of Signaling by Growth Hormone Receptor.
ARGETSINGER, LAWRENCE S. AND CHRISTIN CARTER-SU.
Department of Physiology, University of Michigan Medical School, Ann Arbor,
Michigan
APStracts 2:0033P, 1996.
ABSTRACT
Growth hormone (GH) has long been known to stimulate linear growth and
regulate metabolism. The cellular mechanism by which GH elicits these effects
has only recently begun to be understood. This review provides an overview of
a current model of GH signaling. Briefly, binding of GH to GH receptor induces
receptor dimerization and activation of JAK2 tyrosine kinase. Tyrosyl
phosphorylation of GH receptor and JAK2 recruits and activates signaling
molecules such as Stat transcription factors, SHC, and insulin receptor
substrates 1 and 2 that lead to the release of second messengers such as
diacylglycerol, calcium, and nitric oxide and the activation of enzymes such
as mitogen-activated protein kinase, protein kinase C, phospholipase
A[inf]2[r], and phosphatidylinositol 3[prime]-kinase. These pathways regulate
cellular function including gene transcription, metabolite transport, and
enzymatic activity that result in the ability of GH to control body growth and
metabolism.
APS Manuscript Number P-6.
Article publication pending October 1996, Physiological Reviews.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996