Cellular and Molecular Neuroscience of Alcoholism.
Diamond, Ivan, and Adrienne S. Gordon.
Ernest Gallo Clinic and Research Center, Department of Neurology and the
Neuroscience Program and Department of Cellular and Molecular Pharmacology,
University of California, San Fransisco General Hospital, San Fransisco,
California
APStracts 2:0039P, 1996.
ABSTRACT
Recent advances in neuroscience have made it possible to investigate the
pathophysiology of alcoholism at a cellular and molecular level. Evidence
indicates that ethanol affects hormone- and neurotransmitter-activated signal
transduction, leading to short-term changes in regulation of cellular
functions and long-term changes in gene expression. Such changes in the brain
probably underlie many of the acute and chronic neurological events in
alcoholism. In addition, genetic vulnerability also plays a role in alcoholism
and, perhaps, in alcoholic medical disorders.
APS Manuscript Number P19-6.
Article publication pending January 1997, Physiological Reviews.
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996