Cholecystokinin is involved in both peripheral and central
mechanisms controlling food intake in the chicken.
Rodr[acute]iguez-Sinovas, A., E. Fern[acute]andez, X. Manteca, A. G.
Fern[acute]andez, E. Go[tilde]nalons.
Department of Cell Biology and Physiology. Physiology Unit.
Veterinary Faculty. Autonomous University of Barcelona. 08193
Bellaterra (Barcelona), SPAIN
APStracts 3:0291R, 1996.
The aim of this work was to study the involvement of cholecystokinin
(CCK) in the control of food intake in chickens. The following
aspects were studied. First, the effects of i.v. and i.c.v. sulphated
octapeptide of CCK (CCK-8s) on voluntary food intake; second, the
effects of two CCK-receptor antagonists, L365,260 and L364,718, on
food intake; and third, the ability of such drugs to block the
effects of CCK-8s on food intake in the chicken. I.v. and i.c.v. CCK
-8s caused a decrease in food intake. I.p. L-365,260, a CCK receptor
antagonist with low affinity for the two CCK receptors described in
the chicken, increases food intake. I.c.v. L-364,718, a drug which
has high affinity for the chicken central CCK receptor type,
increased food intake. The effect of i.v. CCK-8s on food intake was
not blocked by L-364,718 or L-365,260, whereas that of i.c.v. CCK-8s
was blocked by i.c.v. L-364,718. It is concluded that central
endogenous CCK plays a role in the control of food intake, which is
dependent on central CCK receptor type; nevertheless, peripheral CCK
also decreases food intake acting on the peripheral CCK receptor
type. The fact that i.c.v. L-364,718 is able to increase food intake
is related to its high affinity for the central CCK receptor type of
this species. Finally, three different speculations, which might
explain the fact that i.p. L-365,260 increases food intake, are
discussed.
Received 26 December 1995; accepted in final form 26 June 1996.
APS Manuscript Number R819-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 4 August 1996