Central infusion of glp-1, but not leptin, produces conditioned
taste aversions in rats.
Thiele, Todd E., Gertjan Van Dijk, L. Arthur Campfield, Francoise J.
Smith, Paul Burn, Stephen C. Woods, Ilene L. Bernstein, and Randy J.
Seeley.
Department of Psychology, Behavioral Neuroscience, and Medicine,
University of Washington, Seattle, WA 98195 and Department of
Metabolic Diseases, Hoffmann-La Roche4, Nutley, NJ 07110
APStracts 3:0391R, 1996.
Leptin (OB Protein) and glucagon-like peptide-1 (7-36) amide (GLP-1)
are peptides recently proposed to be involved in the regulation of
food intake. Although the ability of exogenous leptin and GLP-1 to
modulate consummatory behavior is consistent with the suggestion that
these peptides are endogenous regulatory agents, central
administration of these peptides may have aversive side effects which
could explain the anorexia. In the present experiment, exposure to a
saccharine taste was immediately followed by central administration
of leptin or GLP-1 to determine if these drugs could produce a
conditioned taste aversion (CTA) in rats. At doses equated for
producing comparable reductions in short-term food intake, GLP-1, but
not leptin, generated a robust CTA. Although leptin caused no
aversion, this peptide was the only drug to cause relatively long
-term reductions in food consumption (16-h) and body weight (24-h).
Hence, the results indicate that central GLP-1 produces aversive side
effects, and it is argued that these nonspecific effects may explain
the anorectic actions of GLP-1.
Received 4 September 1996; accepted in final form 30 October
1996.
APS Manuscript Number R530-6.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996