Effects of a23187 and verapamil on the active transport enzymes in
turtle bladder epithelial cells.
Sabatini, Sandra.
Departments of Physiology and Internal Medicine and The Combined
Program in Nephrology and Renal Physiology, Texas Tech University
Health Sciences Center, Lubbock, Texas 79430
APStracts 3:0417R, 1996.
These experiments were designed to examine the effects of A23187 (5 X
10-4M) and verapamil (100 mM) on membrane transport, Ca45 fluxes and
ATPase activities in turtle bladder. In the intact membrane, the
calcium ionophore decreased proton secretion and sodium transport
(SCC) to approximately the same degree (by 55% at 30 min). During the
same period of time, verapamil decreased SCC (by 58%), but proton
secretion was unaffected. The turtle bladder membrane is composed
predominately of two cell types:
Received 10 September 1995; accepted in final form 12 November
1996.
APS Manuscript Number R562-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 31 December 1996