The il-1 type i receptor mediates the apr to turpentine, but not
lps, in mice.
Receptor, Il-1 Type I, and Inflammation 1.
Lisa R. Leon, Carole A. Conn, Moira Glaccum, Matthew J. Kluger
APStracts 3:0259R, 1996.
This study examined the role of the IL-1 type I receptor (IL-1RtI) in
the acute phase response (APR) to inflammation in mice. Turpentine
(100 ml/mouse) injected subcutaneously induced fever, lethargy,
reduced body weight and anorexia in IL-1RtI wildtype mice. Knockout
mice lacking the IL-1RtI were resistant to these effects of
turpentine supporting a role for this receptor in the APR to local
inflammation. The intraperitoneal injection of a low (50 mg/kg) or
high (2.5 mg/kg) dose of lipopolysaccharide (LPS) induced similar
acute phase responses in IL-1RtI wildtype and knockout mice. IL-1RtI
knockout mice were resistant to the APR induced by peripherally
injected murine IL-1b suggesting that it is not the interaction of
endogenous IL-1b with IL-1RtII that induces an APR to LPS in these
mice. We speculate that the absence of IL-1 type I receptors in these
knockout mice results in the sensitization of other cytokine pathways
to mediate the APR to LPS.
Received 15 March 1996; accepted in final form 24 May 1996.
APS Manuscript Number R162-6.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 4 July 96