Lysine acetylsalycilate modifies aphagia and thermogenic changes
induced by lateral hypothalamic lesion.
Monda, M., A. Sullo, E. De Luca, M. P. Pellicano.
Dipartimento di Fisiologia Umana e Funzioni Biologiche Integrate
"Filippo Bottazzi", Seconda Universit[grave]a di Napoli, Via
Costantinopoli 16, 80138 Napoli, Italy, Istituto di Scienze
dell'Alimentazione, C.N.R., Avellino, Italy
APStracts 3:0261R, 1996.
These experiments test the effect of intraperitoneal (ip) injection of
lysine acetylsalicylate on: 1) food intake, 2) the sympathetic and
thermogenic changes induced by lesion of the lateral hypothalamus
(LH). Food intake, firing rate of the nerves innervating
interscapular brown adipose tissue (IBAT), along with IBAT and
colonic temperatures (TIBAT and TC) were monitored in male Sprague
-Dawley rats lesioned in the LH. These variables were measured before
and after intraperitoneal (ip) injection of lysine acetylsalicylate.
The same variables were also monitored in: a) lesioned rats with ip
administration of saline; b) sham-lesioned animals with ip injection
of lysine acetylsalicylate; c) sham-lesioned rats with ip injection
of saline. The results show that lysine acetylsalicylate modifies the
aphagia by increasing food intake and it also reduces the
enhancements in firing rate, TIBAT, and TC induced by LH lesion.
These findings suggest that prostaglandin synthesis plays a key role
in the control of eating behavior in LH lesioned rats, by acting on
the sympathetic and thermogenic changes induced by LH lesion.
Received 12 February 1996; accepted in final form 10 June 1996.
APS Manuscript Number R88-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 4 July 96