Atrial natriuretic hormone inhibits angiotensin ii-stimulated
sympathetic nerve activity in humans.
Matsukawa, Toshiyoshi, and Tadaaki Mano.
Department of Autonomic and Behavioral Neurosciences, Division of
Higher Nervous Control, Research Institute of Environmental Medicine,
Nagoya University, Nagoya 464-01, Japan
APStracts 3:0114R, 1996.
We examined the effect of the intravenous infusion of atrial
natriuretic hormone (ANH) on the response of muscle sympathetic nerve
activity (MSNA) to infused angiotensin II (ANG II) in humans. The
infusion of saline alone or ANH (10 ng. kg-1.min-1) alone produced no
significant change in MSNA, while the infusion of ANG II (5 ng.kg
-1.min-1) alone caused a decrease in MSNA. Because elevations in
arterial pressure (AP) and central venous pressure (CVP) also
occurred due to ANG II, such elevations in AP and CVP could inhibit
MSNA via baroreflexes. Then, the effect of ANG II on AP and CVP was
inhibited by the simultaneous infusion of nitroprusside (N). The
infusion of ANG II (5 ng.kg-1.min-1) produced significant increases
in MSNA when ANG II was infused along with N. However, the
simultaneously infused ANH (10 ng.kg-1.min-1) abolished the increases
in MSNA induced by ANG II when the elevation in AP and CVP was
inhibited by N. Thus, ANH inhibits ANG II-induced sympathetic
activation in humans. The results suggest that ANH may modulate
sympathetic nerve activity at least in part by antagonizing the
action of ANG II.
Received 14 September 1995; accepted in final form 6 March 1996.
APS Manuscript Number R572-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 27 March 96