Interpretation of sham feeding data: curve shift studies.
Weingarten, Harvey P., Anh Duong, and Dawn Elston.
Department of Psychology, McMaster University, Hamilton, Ontario,
Canada L8S 4K1
APStracts 3:0092R, 1996.
WEINGARTEN, H.P., A. DUONG AND D. ELSTON. Interpretation of sham
feeding data: curve shift studies. AM. J. PHYSIOL. We explored the
possibility that quantitative analysis of the relationship between
sucrose concentration and sham intake differentiated how various
treatments affected the intake of sweet solutions. Rats sham fed
sucrose solutions varying in concentration from .03125M to 1.5M.
Under different treatment conditions, intake-concentration functions
were generated which plotted amount sham fed against sucrose
concentration. Sucrose concentrations that yielded 50% maximal sham
intake were calculated to indicate the position of the concentration
-intake function on the X-axis. Quinine adulteration of sucrose
solutions and ip injection of 0.5 mg/kg of the dopamine antagonist
pimozide reduced sham intake and shifted the concentration-intake
function to the right. Lithium chloride (60 mg/kg) injected ip 30 min
before sham feeding, a reduction of food deprivation from 18 to 6 hr
prior to sham feeding, and 6 [mu]g/kg CCK-8 reduced sham intake
equivalent amounts but did not shift the concentration-intake
functions along the X-axis. The data indicate that of several factors
that reduce sham feeding, only some also shift the position of
concentration-intake curves and these curve shifts may identify
intake changes mediated by alterations in the processing of the taste
input.
Received 14 September 1994; accepted in final form 1 March 1996.
APS Manuscript Number R519-4.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 20 March 96