Low frequency ultradian insulin rhythms are coupled to
cardiovascular, autonomic, and neuroendocrine rhythms.
Shannahoff-Khalsa, David S., Brian Kennedy, F. Eugene Yates, and
Michael G. Ziegler.
The Research Group for Mind-Body Dynamics, Institute for Nonlinear
Science (0402), University of California, San Diego, 9500 Gilman Dr.,
La Jolla, CA 92093-0402, Division of Nephrology, Department of
Medicine, University of California, San Diego, San Diego, CA. 92103
-8341, 3 The Khalsa Foundation for Medical Science, Del Mar, CA.
92014, Medical Monitoring Unit, Department of Medicine, University of
California, Los Angeles, CA. 90025-7014
APStracts 3:0383R, 1996.
Plasma insulin levels were assayed to compare with earlier reported
rhythms of the cardiovascular, autonomic, and neuroendocrine systems
in 10 resting normal adults over 5-6 h. Our earlier report included
time series analysis for impedance cardiography measures of stroke
volume, heart rate, cardiac output, thoracic fluid index, ejection
velocity index, and ventricular ejection time; automated cuff
measures of systolic, diastolic, and mean arterial pressures; the
nasal cycle as a marker of lateralized autonomic tone; and indwelling
venous catheters for sampling blood every 7.5 min to assay for
adrenocorticotropin hormone, luteinizing hormone, epinephrine, and
norepinephrine. Insulin was later assayed from the same plasma
samples. Time series analysis using the Fast Orthogonal Search method
of Korenberg detected insulin periodicities at 220-340, 115-145, 70
-100, and 40-65 min ranges with significance across subjects at the
115-145, 70-100, and 40-65 min ranges. Significant periods for the
other parameters were reported earlier at 220-340, 170-215, 115-145,
70-100, and 40-65 min, with periods at 115-145, 70-100, and 40-65 min
dominating across parameters. These results suggest that insulin
secretion has a common pacemaker (the hypothalamus) or a mutually
entrained pacemaker with the autonomic, cardiovascular, and
neuroendocrine systems.
Received 31 July 1996; accepted in final form 15 October 1996.
APS Manuscript Number R446-6.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 5 November 1996