Caudal hindbrain neuromedin b preferring receptors participate in
the control of food intake .
Ladenheim, E. E., J. E. Taylor, D. H. Coy, T. S. Carrigan, A. Wohn,
and .h. Moran.
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins
University School of Medicine, Baltimore, MD 21205, Biomeasure, Inc,
27 Maple Street, Milford, MA 01757, Peptide Research Laboratories,
Department of Medicine, Tulane University Medical Center, New
Orleans, LA 70112
APStracts 3:0387R, 1996.
Recent studies have identified two subtypes of bombesin (BN) receptors
in the rat central nervous system; gastrin releasing-peptide (GRP)
-preferring and neuromedin B (NMB)-preferring. To investigate a role
for the NMB preferring receptor subtype in feeding suppression
elicited by fourth ventricular (4V) BN administration, we evaluated
the ability of a selective NMB-preferring receptor antagonist, BIM
-23127, to block suppression of glucose intake produced by 4V BN (10
pmol). Our results showed that 4V administration of BIM-23127 dose
-dependently antagonized the suppression of glucose intake produced by
4V BN. In addition, 4V administration of BIM-23127 alone increased
glucose intake above that observed in the baseline condition. These
results support a role for the NMB preferring BN receptor subtype in
the suppression of intake produced by 4V BN administration and
suggest that endogenously released NMB participates in ingestive
control.
Received 22 May 1996; accepted in final form 18 September 1996.
APS Manuscript Number R286-6.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 13 November 1996