The av3v neurons which send axons to hypothalamic nuclei respond to
the systemic injection of il-1[beta].
Ota, Kazuki, Toshihiko Katafuchi, Atsushi Takaki, and Tetsuro Hori.
Department of Physiology, Kyushu University Faculty of Medicine,
Fukuoka 812-82, Japan
APStracts 3:0327R, 1996.
The single neuron activity in the anteroventral region of the third
ventricle (AV3V) was extracellularly recorded in urethane and
[alpha]-chloralose anesthetized rats. Electrical stimulation of the
medial preoptic area (mPOA) and the paraventricular nucleus (PVN)
revealed a reciprocal neural connection between the AV3V and these
hypothalamic nuclei with an ipsilateral preponderance. All the AV3V
neurons which were antidromically activated by the stimulation of the
mPOA or the PVN altered their activity following the systemic
injection of IL-1[beta]. On the other hand, only about 60% of the
AV3V neurons that showed orthodromic responses were affected by IL
-1[beta]. In 7 of 9 AV3V neurons which were electrophysiologically
identified to send their axons to the mPOA or the PVN, the rhIL
-1[beta]-induced excitation and inhibition were attenuated by a local
application of sodium salicylate through multibarreled micropipettes.
These results suggest that the AV3V neurons alter their activity in
response to the blood-borne IL-1[beta], at least in part, through a
local synthesis of prostanoids and then send the information to the
mPOA and PVN.
Received 27 November 1995; accepted in final form 19 August 1996.
APS Manuscript Number R738-5.
Article publication pending Am. J. Physiol. (Regulatory Integrative
Comp. Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 19 September 1996