Insulin resistance but igf-i sensitivity in chronic renal
failure.
Mak, Robert H. K.
DIVISION OF NEPHROLOGY, DEPARTMENT OF PEDIATRICS, STANFORD
UNIVERSITY SCHOOL OF MEDICINE, CA.
APStracts 3:0027F, 1996.
The effects of IGF-I and insulin on glucose metabolism were compared
in awake, chronically catheterized rats with chronic renal failure
(CRF) and sham-operated, pair-fed controls (C). In control rats, IGF
-I (5 mg.kg-1.min-1) and insulin (2 mU.kg-1.min-1) infusions produced
similar twofold increases in total body glucose uptake from fasting
values under euglycemic conditions (euglycemic clamps). Total body
glucose uptake during euglycemic IGF-I clamps at 5 mg.kg-1.min-1 and
10 mg.kg-1.min-1 were not different between CRF rats and control
rats. Total body glucose uptake during euglycemic insulin clamps at 2
mU.kg-1.min-1 and 4 mU.kg-1.min-1 were significantly lower in CRF
rats compared with corresponding values in control rats. Hepatic
glucose production was suppressed by insulin equally but not
suppressed by IGF-I in both groups. Correction of metabolic acidosis
by NaHCO3 partially improved insulin resistance in rats with CRF
while an equimolar amount of NaCl had no effect. Thus, the capacity
of IGF-I infusion to stimulate total body glucose uptake is
maintained in CRF rats that are insulin resistant.
Received 7 August 1995; accepted in final form 1 February 1996.
APS Manuscript Number F258-5.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 14 February 96