Effects of intravenous adenosine on renal function in healthy human
subjects.
Balakrishnan, V S, G A Coles & J D Williams.
Institute of Nephrology, University of Wales College of Medicine,
Cardiff Royal Infirmary, Cardiff CF2 1SZ, Wales, United Kingdom, Tel:
(01222) 492233, Fax: (01222) 453643
APStracts 3:0060F, 1996.
The vasoactive nucleoside adenosine has an important regulatory
influence on most aspects of renal function in experimental animals.
In this study, we evaluated the effects of intravenous adenosine on
systemic and renal haemodynamics, tubular function and plasma renin
concentration in ten healthy, male subjects. Each of the subjects
received two intravenous infusions of adenosine (70 [mu]g/kg-1/min-1)
and saline on three separate study days. There was no significant
change in systemic blood pressure in response to adenosine, although
there was a significant rise in heart rate post - commencement of
adenosine (61.5 +/- 2.9 to 78.0 +/- 7.9 bpm, 1-h post - commencement
of adenosine on day 1, P < 0.01 vs saline). There was a
significant decline in 51Cr-EDTA clearance (GFR) (118.5 +/- 13.2 to
88.0 +/- 8.3 ml/min, P < 0.05 vs saline) and filtration fraction
(FF) (19.4 +/- 1.01 to 16.0 +/- 1.03 %, P < 0.01 vs saline) 1 h
post - commencement of adenosine, although there was no significant
change in 125I-hippuran clearance (ERPF). Urine flow rate, osmolar
and free water clearance decreased significantly in response to
adenosine (particularly on study day 1). There was, in addition, a
significant reduction in absolute and fractional excretion rates of
sodium, lithium, phosphate, uric acid, chloride and urea in response
to adenosine. There was a rise in plasma renin concentration (PRC) in
response to adenosine, reaching levels of statistical significance on
study day 1 (15.0 +/- 2.02 to 22.2 +/- 2.00 [mu]U/ml, 1-h post
-commencement of adenosine, P < 0.05 vs saline). These data are
consistent with observations in experimental animals and complement
the results of previous studies in man using a selective adenosine A1
receptor antagonist, thereby confirming that adenosine has a
significant regulatory influence on human renal function.
Received 20 November 1995; accepted in final form 12 March 1996.
APS Manuscript Number F395-5.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 27 March 96