Urodilatin is involved in sodium homeostasis and exerts sodium
-state dependent natriuretic and diuretic effects.
Meyer, Markus, Rudolf Richter, Reinhard Brunkhorst, Eike Wrenger,
Peter Schulz-Knappe, Andreas Kist, Peter Mentz, Ernst G. Brabant,
Karl M. Koch, Gerhard Rechkemmer, and Wolf-Georg Forssmann.
Lower Saxony Institute for Peptide Research, Department of
Nephrology, Hannover Medical School, HaemoPep Pharma GmbH, and
Department of Endocrinology, Hannover Medical School, 30625 Hannover,
Federal Republic of Germany
APStracts 3:0078F, 1996.
Urodilatin is involved in sodium homeostasis and exerts sodium-state
dependent natriuretic and diuretic effects. Eight male volunteers
participated in a study consisting of three consecutive phases, 7
days each. The volunteers received a sodium diet with 52, 172.6 and
347.8 mmol sodium / day. Sodium excretion increased from 57.4 +/- 3.7
mmol / 24 h via 130.8 +/- 4.6 (p < 0.001) to 322.5 +/- 10.2 (p
< 0.001) at the end of each sodium diet. Urinary Urodilatin
excretion increased from 24.8 +/- 3.0 fmol / min via 35.5 +/- 9.0 (p
= 0.07) to 49.0 +/- 3.6 (p < 0.01). At the end of each diet,
Urodilatin was infused for 2 hours at 20 ng / kg bw / min.
Natriuresis increased after low (4.1 to 52.9 mmol / h, p <
0.001), normal (6.9 to 44.9 mmol / h, p < 0.05), and high sodium
diet (20.1 to 102.9 mmol / h, p < 0.001). Diuresis increased
from 174 to 709 ml / h, p < 0.001; 395 to 1026 ml / h, p <
0.05; and 266 to 1339 ml / h, p < 0.001. The present results
indicate that endogenous Urodilatin plays an important role in sodium
homeostasis and renal response to exogenous Urodilatin is modulated
by sodium balance.
Received 6 September 1995; accepted in final form 15 March 1996.
APS Manuscript Number F297-5.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 1 May 96