Growth factors and the kidney: regulation of epithelial cell
movement and morphogenesis.
Cantley, Lloyd G.
Division of Nephrology, Beth Israel Hospital and Harvard Medical
School, Boston, Massachusetts
APStracts 3:0167F, 1996.
The control of epithelial cell movement and shape change is complex
and requires regulation of a broad range of events including cell
-cell adhesion contacts, cell-substratum interactions and the actin
cytoskeleton. Utilizing the hepatocyte growth factor tyrosine kinase
receptor, c-met, the present review examines how growth factor
receptors activate intracellular signalling pathways which can then
regulate the events necessary for epithelial cells to disassemble
their existing structure, undergo extensive shape change and cell
body movement and reassemble into a polarized epithelium. The role of
growth factor mediated activation of the phosphoinositide 3-kinase,
phospholipase Cg, c-src family members and ras family members is
addressed in relation to integrin-mediated cell-basement membrane
contacts, cadherin-mediated cell-cell adhesions, and regulation of
the actin cytoskeleton.
Received 19 July 1996; accepted in final form 5 September 1996.
APS Manuscript Number F208-6.
Article publication pending Am. J. Physiol. (Renal Fluid Electrolyte
Physiology).
ISSN 1080-4757 Copyright 1996 The American Physiological Society.
Published in APStracts on 7 October 1996