The hot ivgtt two compartment minimal model: indices of glucose
effectiveness and insulin sensitivity.
Vicini, Paolo, Andrea Caumo, and Claudio Cobelli.
Department of Electronics and Informatics, University of Padova,
Italy Scientific Institute San Raffaele, Milano, Italy
APStracts 4:0164E, 1997.
A two compartment minimal model (hereafter 2CMM) has been proposed
(Am.J. Physiol. 264: E829-E841, 1993) to describe IVGTT hot glucose
kinetics. This model, at variance with the one compartment model
(hereafter 1CMM), allows the estimation of a plausible profile of
glucose production. The aim of this study is to show that it also
allows to assess insulin sensitivity SI2*, glucose effectiveness SG2*
and plasma clearance rate PCR. The model was identified on stable
isotope IVGTTs performed in normals (N=14). Results were (mean+/
-SEM): SG2*=0.85+/-0.14 ml kg-1 min-1, PCR=2.02+/-0.14 ml kg-1 min-1
and SI2*=13.83+/-2.54 102ml kg-1 min-1 [mu]U-1 ml. The 1CMM was also
identified: indices were SG*V=1.36+/-0.08 mlmin-1kg-1 and
SI*V=12.98+/-2.21 102 ml min-1 kg-1 [mu]U-1 ml. SG*V was lower than
PCR and higher than SG2*, and did not correlate with either (r=0.45,
NS, and r=0.50, NS), while SI*V was not different and correlated with
SI2* (r=0.95; p<0.001). SG* compares well (r=0.78; p<0.001) with
PCR normalized by the total distribution volume, VD. In conclusion,
the 2CMM is a powerful tool to assess glucose metabolism in vivo.
(Accepted for the Modeling in Physiology section).
Received 29 January 1996; accepted in final form 15 July 1997.
APS Manuscript Number E0050-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 27 August 1997