Effect of isolated gh and igf-i deficiency on long-term renal
changes and urinary albumin excretion in streptozotocin diabetic
dwarf rats.
Gr[phi]nbaek, Henning, Pernille Volmers, Signe F. Bj[phi]rn, Ruth
[phi]sterby, Hans [phi]rskov, Allan Flyvbjerg.
Institute of Experimental Clinical Research, Electron Microscopical
Diabetes Research Laboratory, University Institute of Pathology,
Aarhus Kommunehospital, DK-8000 Aarhus C, DENMARK
APStracts 4:0015E, 1997.
Growth hormone (GH) and Insulin-like growth factor I (IGF-I) may play
a role in early diabetic renal and glomerular growth, and in the
later development of experimental diabetic kidney disease. Rats from
a genetic GH/IGF-I deficient dwarf rat strain were made
streptozotocin diabetic with non-diabetic dwarf rats as controls.
GH/IGF-I intact rats with and without diabetes served as controls.
Following 6 months of diabetes, kidney weight and total glomerular
volume increased significantly in GH/IGF-I intact diabetic rats
compared to the non-diabetic GH/IGF-I intact rats (P <0.05),
while the diabetic dwarf rats had insignificant changes compared to
dwarf control rats. By the end of the study urinary albumin excretion
(UAE) increased from similar base levels of about 15-20 [mu]g/24
hours to 473 +/- 52 (SEM) [mu]g/24 hours in GH/IGF-I intacct diabetic
rats compared to 151 +/- 32 [mu]g/24 hours in diabetic dwarf rats (P
<0.01). In conclusion, isolated GH/IGF-I deficiency reduces
the degree of renal and glomerular hypertrophy and the increase in
UAE following six months experimental diabetes in GH/IGF-I deficient
rats.
Received 12 August 1996; accepted in final form 7 January 1997.
APS Manuscript Number E395-6.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 19 February 1997