Effects of exercise in diabetes prior to, and during gestation on
maternal and neonatal outcomes..
Vanheest, Jaci L., and Carol D. Rodgers.
Michigan State University, Department of Physical Education and
Exercise Science, East Lansing, Michigan 48824
APStracts 4:0134E, 1997.
This study was designed to evaluate the effects of chronic endurance
training on glucose and lipid homeostasis in diabetic mothers and
their offspring. Female Sprague-Dawley rats were rendered diabetic
(>20mmol/l glucose) by streptozotocin (STZ) and subdivided into
three (20m/min; 0%grade; 1hr/day; 5days/wk) treatments (n=10/group);
EE=exercise before and during gestation, ES=exercise before gestation
with cessation upon conception, and SS=sedentary prior to and during
gestation. Response of dams to a pre-conception and third trimester
glucose tolerance test, litter number (EE=ES=SS=3) and average litter
size (EE=9.7+1.5; ES=9.0+1.5; SS=8.3+0.3) did not differ between
groups. Number of offspring remaining viable was significantly
different between groups (EE=17;ES=0;SS=14). Response to a glucose
challenge, and fasting glucose and insulin were different between the
EE and SS pups. Exercise prior to, and during gestation did not
reduce the viability of offspring. Cessation of exercise during early
pregnancy negatively affected offspring viability.
Received 13 May 1997; accepted in final form 22 May 1997
APS Manuscript Number E218-7.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 10 July 1997