A kinetic mass balance model for 1,5-anhydroglucitol: applications
to monitoring of glycemic control.
Stickle, Douglas, and John Turk.
Department of Pathology, Division of Laboratory Medicine, and
Department of Medicine, Division of Endocrinology, Diabetes and
Metabolism, Washington University School of Medicine, St. Louis, MO
63110
APStracts 4:0141E, 1997.
The polyol 1,5-anhydroglucitol (AG) present in human plasma is derived
largely from ingestion and is excreted unmetabolized. Reduction of
plasma [AG] has been noted in diabetics and is due to accelerated
excretion of AG during hyperglycemia. Plasma [AG] has therefore been
proposed as a marker for glycemic control. A precise understanding of
its utility relies on a quantitative understanding of the mass
balance for AG. In this study, non-steady-state data from the
literature were analyzed to develop a dynamic mass balance model for
AG that is based on the two-compartment model proposed by Yamanouchi
et al. (Am. J. Physiol. 263:E268, 1992). The data are consistent with
a model in which exchange between tissue and plasma pools is rapid
and in which the tissue compartment mass is 2-3 time the mass of the
plasma compartment. According to model estimates, accelerated
excretion of AG due to hyperglycemia can cause marked net depletion
of total AG over the time scale of days. Recovery from a depleted
state is slow because the total body capacity represents more than
five weeks of normal intake. Accordingly, AG monitoring should be
able to indicate the presence of past glucosuric hyperglycemic
episodes during a days- to weeks-long period, as well as provide
information on the extent to which high deviations from the average
plasma [glucose] are operative. (Accepted for the Modeling in
Physiology section)
Received 4 March 1997; accepted in final form 19 June 1997.
APS Manuscript Number E98-7.
Article publication pending Am. J. Physiol. (Endocrinol. Metab.).
ISSN 1080-4757 Copyright 1997 The American Physiological Society.
Published in APStracts on 10 July 1997